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612827 
Journal Article 
Effect of Oxymetazoline on Healthy Human Nasal Ciliary Beat Frequency Measured With High-Speed Digital Microscopy and Mucociliary Transport Time 
Luo, Z; Han, D; Xiaohong, S; Kuiji, W; Hong, W 
2008 
Yes 
Annals of Otology, Rhinology, and Laryngology
ISSN: 0003-4894 
117 
2 
127-133 
Objectives: We investigated the effects of oxymetazoline hydrochloride on the regulation of healthy human nasal ciliary beat frequency (CBF) and its influence on nasal mucociliary transport time (MIT). Methods: Changes in (cultured) human nasal CBF in response to increasing concentrations of oxymetazoline within 20 minutes were quantified by use of high-speed digital microscopy. Moreover, the MIT before and after application of 0.05% oxymetazoline was determined by use of the saccharin test. Results: Whereas no statistically significant difference was identified when compared to basal CBF at the concentration of 0.025% or 0.05%, both 0.10% and 0.20% oxymetazoline induced a significantly lower CBF at the end of the observation period. The decrement induced by 0.20% oxymetazoline appeared earlier. At concentrations ranging from 0.025% to 0.20%, the inhibitory effect was dependent on the concentration of oxymetazoline. In addition, the use of 0.05% oxymetazoline increased the mean (±SD) human nasal MIT from 474 ± 21 seconds to 572 ± 41 seconds (n = 29). Conclusions: The clinical concentration of oxymetazoline, 0.05%, has no obvious inhibitory effect on human nasal CBF in vitro. The increased MIT caused by 0.05% oxymetazoline in vivo is within the normal range. [ABSTRACT FROM AUTHOR] Copyright of Annals of Otology, Rhinology & Laryngology is the property of Annals Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts) 
NASAL manifestations of general diseases; MUCOCILIARY system; RESPIRATORY infections; RESPIRATORY organs -- Diseases; MICROSCOPY; ciliary beat frequency; mucociliary transport time; nasal epithelial cell; oxymetazoline