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6141376 
Journal Article 
Anticancer Drugs Acting via Radical Species, Photosensitizers and Photodynamic Therapy of Cancer 
Avendano, C; Carlos Menendez, J; Avendano, C; Menendez, JC 
2008 
Elsevier 
Amsterdam 
Medicinal Chemistry of Anticancer Drugs 
93-138 
WOS:000317746500005 
Publisher Summary Cell membranes are one of the biological structures more sensitive to damage by radicals because of the presence of polyunsaturated fatty acids in them, containing methylene groups that are simultaneously adjacent to two double bonds. Oxidative stress by hydroxyl radical also causes direct DNA damage, mainly by strand cleavage and oxidation of pyrimidine and purine bases. Attack of hydroxyl radicals to purine or pyrimidine bases produces other DNA damages. Another consequence of the formation of hydroxyl radicals can be the generation of formaldehyde by reaction with certain cell components like spermine and lipids. Anthracyclines are a group of antibiotics characterized by the presence of a planar chromophore containing an anthraquinone fragment, attached to an amino sugar. Mitoxantrone, an anthraquin one derivative bearing poly amine side chains, can be considered as a partial analog of the anthracyclines including the hydroxyquin one function. The bleomycins (BLMs) are a family of natural glycopeptidic antibiotics produced by Streptomyces verticillus with clinical efficacy against several types of tumors, specially squamous cell carcinoma, testicular carcinoma, and malignant lymphomas. 
Menéndez, J. Carlos