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HERO ID
6142000
Reference Type
Journal Article
Title
The effect of methanol, formaldehyde and formic acid on tissue respiration
Author(s)
Watts, DT
Year
1951
Is Peer Reviewed?
Yes
Journal
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
EISSN:
1096-0384
Volume
34
Issue
2
Page Numbers
391-395
Language
English
PMID
14904074
DOI
10.1016/0003-9861(51)90017-3
Abstract
1. The effect of methanol, formaldehyde, and formic acid on the following enzyme systems has been determined: (a) the oxidation and fermentation of glucose by yeast, (b) the oxidation of glucose by rat liver slices, and (c) the oxidation of ascorbate and succinate by rat liver homogenates.
2. The order of inhibition was formaldehyde formic acid methanol. Formaldehyde was a very potent inhibitor, whereas the other compounds were comparatively weak enzymatic inhibitors.
3. The possible relationship of these enzymatic inhibitors to methanol poisoning is discussed.
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