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Citation
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HERO ID
615375
Reference Type
Journal Article
Title
Waterleaf (Talinum triangulare) Enhances Cerebral Functions in Swiss albino mice
Author(s)
Ofusori, DA; Adelakun, AE; Ayoka, AO; Oluwayinka, OP; Omotoso, EO; Odukoya, SA; Adeyemi, DO
Year
2008
Is Peer Reviewed?
Yes
Journal
Journal of Neurological Sciences (Print)
ISSN:
1302-1664
Volume
25
Issue
4
Page Numbers
239-246
Web of Science Id
WOS:000264311800005
Abstract
The aim of this investigation was to verify the effect of aqueous extract of waterleaf commonly used as food supplement on the cerebrum of Swiss albino mice. Forty mice of both sexes were randomly assigned into three treatments (n=30) and control (n=10) groups. The mice in the treatment groups-B, C and D respectively received 20mg, 30mg and 40mg of waterleaf extract for fourteen consecutive days, while the control mice (group A) received equal amount of normal saline. The cerebral tissues were assayed for Malondialdehyde (MDA) and catalase activities while some were fixed in 10% formol calcium for routine histological study. The histological findings after Haematoxylin and Eosin (H&E) staining indicated that the treated sections of the cerebrum showed no degenerative changes and no intercellular vacuolations in the stroma. There was also a dose dependent reduction (p<0.05) in MDA activities in the treated groups demonstrating the ability of waterleaf to inhibit oxidative stress thus preventing neuronal injury. These findings indicate that waterleaf consumption has benefiting effects on the neurons of the cerebrum and may probably enhance the cognitive ability in Swiss albino mice. (English) [ABSTRACT FROM AUTHOR] Bu araştırmanın amacı sarmaşık dalı (Talinum triangulare) ekstrelerinin sıvı şeklinin ilave bir besin kaynağı olarak İsviçre beyaz sıçanlarının beyin fonksiyonlarına yararlı etkisini göstermektir. Her iki cinsten toplam 40 sıçan üç ayrı tedavi rejimi (n=30) ve kontrol (n=10) grubu olarak gelişigüzel belirlendi. Tedavi gruplarındaki sıçanlar sırasıyla B,C,D olarak 20mg, 30mg ve 40mg sarmaşık dalı ekstresi alırken kontrol grubundaki sıçanlar (grup A) 15 gün boyunca sadece normal tuzlu su aldılar. Serebral dokular malondialdehid (MDA) ve katalaz aktiviteleri için araştırılırken bazıları %10 formol ile fikse edilip rutin histolojik incelemeye alındılar. Hematoksilen ve eosin ile (H&E) boyama sonucu elde edilen histolojik bulgularda tedavi edilen gruptaki beyin kesitlerinde dejeneratif değişikliklere, hücre içi ya da stromal vakuolleşmelere rastgelinmedi. Tedavi edilen gruplarda doza bağımlı olarak saptanan MDA aktivitelerinde bir azalma (p<0,05) saptandı. Bu durum nöronal hasarlanmayı önleyici olarak sarmaşık dalının oksidatif stresi inhibe etme yeteneği ile yorumlandı. Bu bulgular İsviçre beyaz sıçanlarında sarmaşık dalı ile beslenmenin beyindeki nöronlara olumlu etkisi ile bilişsel yeteneğin güçlendirilebileceğini göstermektedir. (Turkish) [ABSTRACT FROM AUTHOR] Copyright of Journal of Neurological Sciences is the property of Journal of Neurological Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts)
Keywords
BRAIN -- Localization of functions; MICE as laboratory animals; MALONDIALDEHYDE; CATALASE; NEURONS; ALBINOS & albinism; HEMOPROTEINS; EOSIN; SWITZERLAND; Cerebrum; histology; MDA; waterleaf; Beyin; histoloji; katalaz; sarmaşık dalı
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