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6175344 
Journal Article 
Abstract 
P048 Lifetime occupational exposure to wood dust and risk of nasal and nasopharyngeal cancer - a case-control study among men in four nordic countries 
Kjaerheim, K; Martinsen, JI; Pukkala, E; Siew, SSA; Sparen, P; Tryggvadottir, L; Weiderpass, E 
2016 
1 
Occupational and Environmental Medicine
ISSN: 1351-0711
EISSN: 1470-7926 
73 
Suppl 1 
A137 
English 
is summary of 4166120 Occupational exposure to wood dust and risk of nasal and nasopharyngeal cancer: A case-control study among men in four nordic countries-With an emphasis on nasal adenocarcinoma
IntroductionThe ambiguity in carcinogenicity of softwood dust intrigued the current study to explore stronger evidence on risk of nasal cancer attributable to lifetime cumulative exposure (CE) to softwood-predominated mixed wood dust across broad wood-processing industries in four Nordic countries.MethodA population-based case-control study was conducted on all male cases with nasal adenocarcinoma (393 cases), other types of nasal cancer (2446), and nasopharyngeal cancer (1747) diagnosed in Finland, Sweden, Norway, and Iceland between1961 and 2005. For each case, five male controls, who were alive at the time of diagnosis of the case (index date), were randomly selected, matched by birth-year and country. CEs to wood dust and formaldehyde before the index date were quantified with job-exposure matrix based on occupational titles derived from population censuses.ResultsHazard ratios (HRs) and 95% confidence intervals (CIs) for the CE of wood dust were estimated by conditional logistic regression, adjusted for CE to formaldehyde. There was an increasing risk of nasal adenocarcinoma related to wood dust exposure. The HR in the highest CE category of wood dust ( greater than or equal to 28.82 mg/m3-years) was 16.5 (95% CI: 5.05-54.1). Neither non-adenocarcinoma of the nose nor nasopharyngeal cancer could be linked to wood dust exposure.ConclusionLifetime CE to softwood-predominated mixed wood dusts is strongly linked to risk of nasal adenocarcinoma but not other types of nasal or nasopharyngeal cancer. 
Toxicology Abstracts; Health & Safety Science Abstracts; Wood dust; nasal adenocarcinoma.; Adenocarcinoma; ANE, Norway; ANE, Sweden; ANE, Atlantic, Iceland; Health risks; Occupational exposure; Formaldehyde; ANE, Finland; Carcinogenicity; Softwoods; X 24350:Industrial Chemicals; H 1000:Occupational Safety and Health 
Occupational Health: Think Globally, Act Locally, EPICOH 2016, September 4–7, 2016, Barcelona, Spain