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618551 
Journal Article 
Uric Acid: The Oxidant-Antioxidant Paradox 
Sautin, YY; Johnson, RJ 
2008 
1 
Nucleosides, Nucleotides and Nucleic Acids
ISSN: 1525-7770 
27 
6/7 
608-619 
English 
18600514 
WOS:000257338600014 
Uric acid, despite being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell). We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions. [ABSTRACT FROM AUTHOR] Copyright of Nucleosides, Nucleotides & Nucleic Acids is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts) 
URIC acid; BLOOD plasma; OBESITY; OXIDATIVE stress; ALLOXAN; cardiovascular disease; metabolic syndrome; redox homeostasis