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6194800 
Journal Article 
Bacterial Utilization of Pure and Mixed C sub(1) Compounds for Single Cell Protein Production 
Hirt, W; Lim, HC; Papoutsakis, E 
1981 
Yes 
Biotechnology and Bioengineering
ISSN: 0006-3592
EISSN: 1097-0290 
23 
1 
235-242 
Small quantities of formaldehyde and formated are usually found in methanol produced by a simple oxidation process from natural gas; this process is of vital importance for the production of methanol to be used for SCP production. It is therefore important to examine the possibility of using the crude methanol without removing formaldehyde and formate, for obvious reasons of lower carbon cost. Although all C sub(1) compounds are growth-inhibitory substrates, formate and especially formaldehyde are considerably more toxic to growth than methanol, both for yeasts and bacteria. As far as is know, however, no RMP-cycle microorganisms or yeasts can grow continuously on either pure fomaldehyde or pure formate. Chemostatic biomass yields on mixed substrates are reported here for the bacterium Methylomonas) L3. The authors show the significant effect that the culture pH has on the chemostatic biomass yield of the same microorganism grown omethanol alone. Some further observations, related to the utizization of C sub(1) compounds by species L3, are also discussed and comparisons are made with the behavior of yeasts. 
methanol; Microbiology Abstracts A: Industrial & Applied Microbiology; single-cell protein; Methylomonas; chemostats; pH effects; A 01002:Acids, amino acids, peptides & proteins; A 01063:Utilization