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620758 
Journal Article 
ANTIOXIDANT STATUS IN CANINE CANCER PATIENTS 
Tanja, P; Alenka, NS; Butinar, J; Nataša, T; Marija, P; Bettina, K; Kessler, M 
2008 
Yes 
Acta Veterinaria
ISSN: 0567-8315 
58 
2/3 
275-286 
WOS:000258838000017 
The present study was conducted to investigate the
antioxidant status in canine cancer patients. Patients with multicentric lymphoma, oral
fibrosarcoma, mast cell tumour, malignant melanoma, appendicular osteosarcoma, nasal tumours and
peripheral ameloblastoma were selected. Each group consisted of 6 patients. Total antioxidant
capacity (TAC) and enzyme antioxidants: glutathione peroxidase (GPX), catalase (CAT) and
superoxide dismutase (SOD) were measured in serum and whole blood, respectively, and were
compared to 31 healthy dogs. The results of the study showed a significant increase of CAT
activity in tumour groups except in the patients with nasal tumours. SOD activity increased
significantly in malignant melanoma, mast cell turnout, multicentric lymphoma and oral
fibrosarcoma patients. Appendicular osteosarcoma and multicentric lymphoma patients showed
significantly increased levels of GPX and TAC, respectively. Activities of CAT and SOD were
significantly higher comparing the all 42 cancer patients with healthy dogs. Tumor patients
showed significantly lower levels of haemoglobin when compared to healthy dogs. The increase of
antioxidant enzyme activities and TAC in these animals suggest the activation of antioxidant
defence mechanisms in different cancer diseases. Further studies involving more animals and other
antioxidant parameters and oxidative stress markers are necessary. 
CANCER; CATALASE; DOGS; PEROXIDASE; GLUTATHIONE; SUPEROXIDE dismutase; ANTIOXIDANTS; dog; glutathione peroxidase; total antioxidant capacity