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6209849 
Journal Article 
Comparative anti-phlogistic activity of Δ9-tetrahydrocannabinol, hydrocortisone and aspirin in various rat paw edema models 
Duane Sofia, R; Knobloch, LC; Nalepa, SD; Vassar, HB 
1974 
1 
Life Sciences
ISSN: 0024-3205
EISSN: 1879-0631 
15 
2 
251-260 
The anti-edema activity of THC has been directly compared to that of hydrocortisone and aspirin in rat paw edemas produced by eleven different phlogistic agents. A significant effective dose for THC could only be achieved in carrageenan, dextran, formalin, kaolin and Na urate induced edemas, while hydrocortisone and aspirin were active against all edemas except that produced by serotonin. Based on these data it is suggested that the anti-edema effects of THC most likely occur by a different mode of action than either the classic steroid or non-steroidal anti-inflammatory agents.