Health & Environmental Research Online (HERO)


Print Feedback Export to File
6231178 
Book/Book Chapter 
10.06 - Alcohol Dehydrogenases 
Bosron, WF; Edenberg, HJ 
2018 
Elsevier 
Oxford 
Comprehensive Toxicology (Third Edition) 
126-145 
The family of mammalian alcohol dehydrogenases are widely expressed and catalyze the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and formaldehyde, among many others. Variations in the structure and expression of these enzymes are associated with differences in risk for alcoholism and for alcohol-related organ damage, including cancer. This article reviews the structure, regulation, and substrate specificity of these enzymes and their potential roles in pharmacogenetics and disease. Future studies of these enzymes should include more attention to how genetic variations affecting both coding and regulation influence risk for disease. 
Alcohol; Alcohol dehydrogenase; Alcoholism; Aldehyde; Catalytic mechanism; Formaldehyde; Gene expression; Metabolism; Polymorphisms; Regulation; Retinol; Structure; Substrate selectivity 
McQueen, Charlene A.