Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

626437

Reference Type

Journal Article

Title

Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells

Author(s)

Grafstrom, RC; Fornace, AJ, Jr; Autrup, H; Lechner, JF; Harris, CC

Year

1983

Is Peer Reviewed?

Yes

Journal

Science
ISSN: 0036-8075
EISSN: 1095-9203

Volume

220

Issue

4593

Page Numbers

216-218

Language

English

PMID

6828890

DOI

10.1126/science.6828890

Web of Science Id

WOS:A1983QH95800041

URL

http://www.sciencemag.org/cgi/doi/10.1126/science.6828890
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Abstract

Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair.

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