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Citation
Tags
HERO ID
627523
Reference Type
Journal Article
Subtype
Review
Title
Molecular mechanisms of arsenic carcinogenesis
Author(s)
Huang, C; Ke, Q; Costa, M; Shi, X
Year
2004
Is Peer Reviewed?
1
Journal
Molecular and Cellular Biochemistry
ISSN:
0300-8177
EISSN:
1573-4919
Volume
255
Issue
1-2
Page Numbers
57-66
Language
English
PMID
14971646
DOI
10.1023/b:mcbi.0000007261.04684.78
Web of Science Id
WOS:000187068800008
Abstract
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.
Keywords
arsenic; carcinogenesis; gene expression; reactive oxygen species; genetic toxicity; signal transduction; kinase; methylation
Tags
IRIS
•
Arsenic (Inorganic)
2. Initial Filter
Reviews
•
Arsenic MOA
4. Adverse Outcome Pathways
•
Inorganic Arsenic (7440-38-2) [Final 2025]
1. Initial Lit Search
PubMed
WOS
ToxNet
3. Initial Filter through Oct 2015
Reviews
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