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627523 
Journal Article 
Review 
Molecular mechanisms of arsenic carcinogenesis 
Huang, C; Ke, Q; Costa, M; Shi, X 
2004 
1 
Molecular and Cellular Biochemistry
ISSN: 0300-8177
EISSN: 1573-4919 
255 
1-2 
57-66 
English 
14971646 
WOS:000187068800008 
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways. 
arsenic; carcinogenesis; gene expression; reactive oxygen species; genetic toxicity; signal transduction; kinase; methylation 
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