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HERO ID
627607
Reference Type
Journal Article
Title
Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterans and matched controls
Author(s)
Kahn, PC; Gochfeld, M; Nygren, M; Hansson, M; Rappe, C; Velez, H; Ghent-Guenther, T; Wilson, WP
Year
1988
Is Peer Reviewed?
Yes
Journal
JAMA: Journal of the American Medical Association
ISSN:
0098-7484
EISSN:
1538-3598
Publisher
AMER MEDICAL ASSOC
Location
UNITED STATES
Volume
259
Issue
11
Page Numbers
1661-1667
Language
English
PMID
3343772
DOI
10.1001/jama.1988.03720110023029
Web of Science Id
WOS:A1988M390300026
URL
http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.1988.03720110023029
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Abstract
Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r = +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.
Keywords
Pilot Projects; Body Burden; Humans; Half-Life; Benzofurans; Adipose Tissue; Veterans; Dioxins; 2,4-Dichlorophenoxyacetic Acid; Index Medicus; Abridged Index Medicus; Male; 2,4,5-Trichlorophenoxyacetic Acid; Tetrachlorodibenzodioxin; 1988)
Tags
IRIS
•
Dioxin (2012 Project Page for Final Report)
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