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62958 
Journal Article 
Abstract 
Lack of manifestation of toxicity in rats inhaling 111 ppm 1,4-dioxane for two years 
Torkelson, TR; Leong, BKJ; Kociba, RJ; Richter, WA; Gehring, PJ 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
86 
English 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Repeated 7-hr daily exposures to an average concentration of 111 ppm (0.4 mg/liter) 1,4-dioxane vapors were given 5 days/week for 2 years to groups of 288 male and 288 female Wistar strain rats. Groups of 192 male and 192 female rats similarly exposed to filtered room air served as controls. There were no observable compound-related effects with respect to demeanor, growth or mortality rate. Hematological studies during the 18th and 23rd months of exposure revealed no deviations from controls. Clinical chemical values determined at the termination of the experiment were within normal limits. Gross and microscopic examination of the major organs and tissues revealed no treatment-related lesions. In this study, no hepatic or nasal carcinomas were observed, although they have been reported to occur in rats maintained on water containing higher levels of dioxane. The incidence of all types of tumors in the control and exposed groups was not statistically different. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974