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6302249 
Journal Article 
The Acute Oral Toxicity of Acetic, Chloracetic, Diehloracetie and Triehloracetic Acids 
Woodard, G; Lange, SW; Nelson, KW; Calvery, HO 
1941 
Yes 
Journal of Industrial Hygiene and Toxicology
ISSN: 0095-9030 
2 
English 
All these acids have been used, or proposed for use, as antiseptics or preservatives. In order to determine the relative toxicities of, the acid radicals. and not their toxicities as acids they were adjusted before feeding with sodium hydroxide to a range of pH between 6 and 7. The concentrations were such that the animals received approximately 0.01 cc., of solution per gramme of body weight. Mice, rats and guineapigs were fed. Animals receiving the acetic, dichloracetic and, trichloracetic acids quickly passed to a state of narcosis and within 36 hours either recovered completely or died without coming out of the narcosis. Those fed with cloracetic acid usually showed no immediate symptoms but became apathetic and rapidly lost weight. If death resulted it was within, 1-3 days. This was the least toxic. The L.D. 50's (in grammes per kilogramme) are for mice, acetic acid, 4.96, chloracetic acid 0.255, dichloracetic acid 5.52, trichloracetic acid 4.97. The respective rat figures are 3.31, 0.076, 4.48, 3.32. W. G. Savage.