US EPA

6303782 

Journal Article 

Correlative relationships between the specific binding of labeled adrenoligands in the brain and plasma testosterone in mice 

Shishkina, GT; Naumenko, EV 

1994 

1 

Neuroscience and Behavioral Physiology
ISSN: 0097-0549
EISSN: 1573-899X 

24 

5 

405-407 

English 

7838362 

10.1007/bf02359792 

Brain norepinephrine (NE) intensifies the release of luliberin from the hypothalamus [11], as well as increases the content of luteinizing hormone (LH) [1, 4] and testosterone (T) [10] in the blood plasma. However, the suppression of the hypothalamohypophyseogonadal system may also be observed in response to central administration of NE [12, 13, 14]. The nature of the dual influence of NE has been related to a dependance of the direction of its action on the endocrine status of animals [6], the dose used of the preparation and the brain division [12, 13], as well as on the involvement of various subtypes of adrenoreceptors in the respondent reaction [14]. Despite the multiplicity of investigations studying the role of the individual subtypes of adrenoreceptors in the regulation of the hypothalamohypophyseogonadal system, it remains in many respects unclear. New possibilities for the investigation of this problem have been opened up in connection with the use of pedigreed animals of various genotypes which differ with respect to the number of adrenoreceptors in the brain [15]. Analysis of the correlative relationships between the specific binding of labeled adrenoligands in the frontal cortex and hypothalamus and T in the blood plasma of male mice of inbred lines, which is the aim of the present study, may foster the determination of the role of central adrenoreceptors in the determination of the basal level of the male sex hormone.