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6311484 
Journal Article 
Insertion of semifluorinated diblocks on DMPC and DPPC liposomes. Influence on the gel and liquid states of the bilayer 
Sabin, J; Prieto, G; Estelrich, J; Sarmiento, F; Costas, M 
2010 
Yes 
Journal of Colloid and Interface Science
ISSN: 0021-9797
EISSN: 1095-7103 
ACADEMIC PRESS INC ELSEVIER SCIENCE 
SAN DIEGO 
348 
2 
388-392 
English 
20483424 
WOS:000279968700014 
Differential Scanning Calorimetry (DSC) was used to study the effect of the incorporation of a series of semifluorinated diblocks FnHm (F6H10, F6H16, F8H14, F8H16, F8H18 and F8H20) on the gel and liquid states of the bilayer of large multilamellar DMPC and DPPC liposomes. The presence of the FnHm diblocks affects slightly the T-m of the main gel-liquid transitions of DMPC and DPPC, but is accompanied by the appearance of a second transition in the calorimetric traces whose T-m is mainly determined by the length of the F-n segment. The DSC results are consistent with the previously established conclusion that the F-n segments of the diblocks form a central layer in the core of the lipid bilayer, with the H-m segments being interdigitated with the lipid chains. The DSC traces suggest that the structure of the fluorinated liposomes is a double bilayer at 3:4 and 1:2 and a trilayer at 2:1 lipid/FnHm molar ratios. At temperatures between the two phase transitions T-m's, the fluorinated liposomes are neither in a gel-like or a liquid-like state but rather posses both characteristics. (C) 2010 Elsevier Inc. All rights reserved. 
Fluorinated liposomes; FnHm; DSC; Phase transitions; Double bilayer; Trilayer