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63167 
Technical Report 
Ethyl chloride: Inhalation teratology study in CF-1 mice 
Scortichini, BH; Johnson, KA; Momany-Pfruender, JJ; Hanley, TR 
1986 
Dow Chemical 
Midland, MI 
OTS0517038. 86-870002248. TSCATS/309650 
English 
The objective of this study was to evaluate the teratogenic potential of inhaled ethyl chloride (EtCl) in CF-1 mice. Groups of 30 bred mice were exposed to EtCl vapors at concentrations of 0, 500, 1500, or 5000 ppm (0, 1.3, 4.0 and 13.2 mg/l air) for 6 hours per day on days 6 thorugh 15 of gestation. No significant effects on maternal body weights, liver weights, reproductive parameters or fetal body weights were observed at any of the exposure levels tested. Examination of fetal mice for external, visceral and skeletal malformations failed to produce any indication of a teratogenic response. A small increase in the incidence of foramina of the skull bones (small centers of unossified bone) suggestive of, at most, very slight fetotoxicity was observed only at the high exposure concentration (5000 ppm). In conclusion, exposure to ethyl chloride at concentrations up to 5000 ppm during the period of major organogenesis did not produce a teratogenic response in fetal mice. 
OTS0517038 
TSCATS/309650