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6316859 
Journal Article 
1 H-guided reconstruction of 19 F gas MRI in COPD patients 
Obert, AJ; Gutberlet, M; Kern, AL; Kaireit, TF; Grimm, R; Wacker, F; Vogel-Claussen, J 
2020 
1 
Magnetic Resonance in Medicine
ISSN: 0740-3194
EISSN: 1522-2594 
84 
3 
1336-1346 
English 
32060989 
WOS:000513340100001 
PURPOSE: To reduce acquisition time and improve image quality and robustness of ventilation assessment in a single breath-hold using 1 H-guided reconstruction of fluorinated gas (19 F) MRI.

METHODS: Reconstructions constraining total variation in the image domain, L1 norm in the wavelet domain, and directional total variation between 19 F and 1 H images were compared in order to accelerate 19 F ventilation imaging using retrospectively undersampled data from a healthy volunteer. Using the optimal constrained reconstruction in 8 patients with chronic obstructive pulmonary disease (16-seconds breath-hold), ventilation maps of various acceleration factors (2-fold to 13-fold) were compared with maps of the full data set using the Dice coefficient, difference in volume defect percentage and overlap percentage, as well as hyperpolarized 129 Xe gas MRI.

RESULTS: The reconstruction constraining total variation and directional total variation simultaneously performed best in the healthy volunteer (RMS error = 0.07, structural similarity index = 0.77) for a measurement time of 2 seconds. Using the same reconstruction in the patients with chronic obstructive pulmonary disease, the Dice coefficient of defect volumes was 0.86 ± 0.05, the mean difference in volume defect percentage was -1.0 ± 1.7 percentage points, and the overlap percentage was 87% ± 2% for a measurement time of 6 seconds. Between volume defect percentage of 19 F and 129 Xe, a linear correlation (r = 0.75; P = .03) was found, with 19 F volume defect percentage being significantly higher (mean difference = 11%; P = .04).

CONCLUSION: 1 H-guided reconstruction of pulmonary 19 F gas MRI enables reduction of acquisition time while maintaining image quality and robustness of functional parameters. 
Medical Sciences--Radiology And Nuclear Medicine; 1 H‐guided reconstruction; perfluoropropane; pulmonary MRI; ventilation; Obstructive lung disease; Chronic obstructive pulmonary disease; Magnetic resonance imaging; Defects; Image reconstruction; Constraining; Variation; Medical imaging; Xenon 129; Lung diseases; Parameter robustness; Image acquisition; Image quality; Domains; Robustness; Time measurement