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63327 
Journal Article 
Abstract 
The effect of carbaryl on reproduction in the monkey (Macacca mulatta) 
Dougherty, WJ; Golberg, L; Coulston, F 
1971 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
19 
2 
365 
English 
is part of a larger document 3479581 Abstracts of papers for the Tenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 7–11, 1971
Carbaryl (l-naphthyl-N-methylcarbamate) is known to affect embryonic development and reproductive function in various species. The purpose of this investigation was to examine its effect on reproduction in the nonhuman primate. Mature female rhesus monkeys (M. mulatta) with regular menstrual cycles were mated with males having a proved record of fertility. Subsequently, the females were treated po with Carbaryl (2 mg/kg or 20 mg/kg) in 1 y0 aqueous gum tragacanth, daily throughout the entire gestation period. Control females received only the suspending medium. Five control monkeys conceived; 4 of these delivered normal infants, and one aborted. (The spontaneous abortion rate among untreated females in our colony is approximately 12 %.) Two of 4 monkeys receiving 2 mg/kg of Carbaryl conceived and both of these aborted. Six of 10 monkeys receiving 20 mg/kg conceived; 3 of these delivered normal infants and the remaining 3 pregnancies ended in abortion. Examination of the live infants, and of some of the aborted fetuses, revealed no gross developmental abnormality in any of the groups. It appears that in the rhesus monkey, the administration of Carbaryl does not produce any teratologic effect, but is associated with a higher rate of abortion as compared with the control group. (Supported by Food and Drug Administration Contract No. FDA 67-30, by Research Grant 5POl-ESOO226-04 from the National Institute of Environmental Health Sciences, NIH, and by the National Institutes of Health Training Grant ES 00103-04.) 
Tenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 7–11, 1971