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6351656 
Journal Article 
Synthesis of local anesthetic dyclonine hydrochloride 
Lu, D; Yan, G; Wang, X; Ji, W; Liu, T; Ling, X 
2016 
Yes 
Chinese Journal of Bioprocess Engineering
ISSN: 1672-3678 
14 
5 
Dyclonine hydrochloride is commonly used as local anesthetics. We developed an efficient synthesis process of dyclonine hydrochloride,namely a novel two-step synthesis process. In this process,4-hydroxyacetophenone and n-butyl bromide were used as the starting material,the intermediate 1-( 4-butoxyphenyl)-ethanone was produced by using the phase-transfer catalyst, and then dyclonine hydrochloride was obtained by further reacting with piperidinium chloride and paraformaldehyde. The structures of dyclonine hydrochloride were confirmed by1H-NMR and MS. The overall yield was more than 90%. It is an easy operation process and suitable for industrial production. 
Local anesthetics; Chloride; Catalysts; bromides/