Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure (Electronic supplementary information (ESI) available. CCDC 1822550 and 1822087. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ob01713a) | Health & Environmental Research Online (HERO)

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HERO ID

6354111

Reference Type

Journal Article

Title

Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure (Electronic supplementary information (ESI) available. CCDC 1822550 and 1822087. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ob01713a)

Author(s)

Jiang, Y; Shuo-Wen, Y; Yang, Y; Ying-Le, L; Xiao-Ying, X; Xiao-Mei, Z; Wei-Cheng, Y

Year

2018

Volume

Issue

Page Numbers

6647-6647

Abstract

A general method for the synthesis of chiral pentacyclic spirooxindoles containing a tetrahydropyrano[2,3-b]indole scaffold through a one-pot stepwise sequence from 3-(3-indolomethyl)oxindole, paraformaldehyde and NCS is reported. Furthermore, the pentacyclic spirooxindoles could be transformed to bispirooxindole and other structurally diverse spirocyclic oxindoles.

Keywords

Indole; Crystallography; Catalysis; Aldehydes; Chemical synthesis/