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6400331 
Journal Article 
COOMBS-POSITIVE HEMOLYTIC-ANEMIA AND IBUPROFEN 
Law, IP; Wickman, CJ; Harrison, BR 
1979 
1 
Southern Medical Journal
ISSN: 0038-4348
EISSN: 1541-8243 
72 
6 
707-710 
English 
451658 
WOS:A1979HG86700022 
A patient who developed an autoimmune hemolytic anemia during treatment with ibuprofen (Motrin) is described. Positive indirect Coombs' reaction was demonstrated with the patient's red blood cell eluate in the presence of the drug, supporting a drug-related immune hemolysis. The positive direct Coombs' reaction to anti-C3 antiserum strongly suggested that the immune hemolysis in this patient is probably mediated through complement alone; however, the presence of a small amount of IgG antibodies on the surface of the red blood cells which cannot be detected under conventional screening procedures cannot be completely excluded. Further studies, both clinical and laboratory, disclosed that the responsible ingredient in this particular instance appeared to be the orange dye coating of the Motrin-400 tablet rather than the ibuprofen itself. 
Azo Compounds; Complement C3; Immune Sera; Immunoglobulin G; Tablets; Tartrazine; Ibuprofen; Aged; Anemia; Hemolytic; Autoimmune/chemically induced/immunology; Azo Compounds/adverse effects; Complement C3; Coombs Test; Humans; Ibuprofen/therapeutic use; Immune Sera; Immunoglobulin G; Male; Osteoarthritis/drug therapy; Tablets; Tartrazine/adverse effects