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HERO ID
6404387
Reference Type
Journal Article
Title
Gender Differences in Depression: Biological, Affective, Cognitive, and Sociocultural Factors
Author(s)
Hyde, JS; Mezulis, A
Year
2020
Is Peer Reviewed?
Yes
Journal
Harvard Review of Psychiatry
ISSN:
1067-3229
Volume
28
Issue
1
Page Numbers
4-13
Language
English
PMID
31913978
DOI
10.1097/HRP.0000000000000230
Web of Science Id
WOS:000507605600002
Abstract
The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-analytically over all ages and nations. The gender difference appears by age 12, OR = 2.37, and peaks at OR = 3.02 for ages 13-15. Using the ABC (affective, biological, cognitive) model as a framework within a vulnerability-stress approach, we consider the evidence for biological vulnerabilities (genes, pubertal hormones, and pubertal timing), affective vulnerabilities (temperament), and cognitive vulnerabilities (negative cognitive style, objectified body consciousness, and rumination). The impact of stress is central to the vulnerability-stress model, and we review evidence on gender differences in stress exposure, emphasizing gender differences in sex-related traumas such as child sexual abuse and rape. Finally, we examine sociocultural factors that may contribute to the gender difference, including the media and gender inequality. An implication for research methods is that single-gender designs should be questioned. Regarding clinical implications, the vulnerabilities and stressors identified in this review should contribute to personalized interventions with depressed individuals, especially depressed women.
Keywords
child sexual abuse; depression; gender differences; genetics; media; negative cognitive style; objectified body consciousness; puberty; rumination; stress
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