Health & Environmental Research Online (HERO)


Print Feedback Export to File
6408827 
Journal Article 
Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function 
Heger, S; Müller, M; Ranke, M; Schwarz, HP; Waldhauser, F; Partsch, CJ; Sippell, WG 
2006 
1 
Molecular and Cellular Endocrinology
ISSN: 0303-7207
EISSN: 1872-8057 
254-255 
217-220 
English 
16757104 
WOS:000239616900029 
Depot gonadotropin releasing hormone (GnRH) agonist (GnRHa) therapy is the treatment of choice for patients with central precocious puberty (CPP). It is still unclear whether long-term exposure to GnRHa is associated with impaired reproductive function in adulthood. The present study was performed on 46 women, former CPP patients, 12.5+/-3.7 years after the discontinuation of treatment with depot GnRHa. In a structured interview, we assessed general health status, clinical signs possibly associated with hyperandrogenism, menstrual cycle, gynaecological diseases and reproductive function. It appears that long-term treatment with depot GnRHa is safe and does not impair reproductive function. The risk of former CPP patients to develop hirsutism and/or polycystic ovary syndrome does not seem to be increased compared to the normal population but this issue needs to be addressed in further long-term follow-up studies.