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6418975 
Journal Article 
Vitamin E requirement of adult cats increases slightly with high dietary intake of polyunsaturated fatty acids 
Hendriks, WH; Wu, YB; Shields, RG; Newcomb, M; Rutherfurd, KJ; Belay, T; Wilson, J 
2002 
Yes 
Journal of Nutrition
ISSN: 0022-3166
EISSN: 1541-6100 
132 
6 Suppl 2 
1613S-5S 
English 
12042472 
  Over the last 50 years there have been numerous reports of vitamin E deficiency in cats with the main cause of these deficiencies being attributed to ingestion of diets high in polyunsaturated fatty acids (PUFAs). Hendriks et al determine the vitamin E requirements of adult cats fed high dietary levels of PUFAs from fish oil.   EXPANDED ABSTRACT Over the last 50 y there have been numerous reports of vitamin E deficiency in cats with the main cause of these deficiencies being attributed to ingestion of diets high in polyunsaturated fatty acids (PUFAs(4) ). Steatitis (yellow fat disease) is attributed to vitamin E deficiency and has been experimentally induced in kittens after feeding a commercial cat food with a high fish content (1 ) and after feeding vitamin E-deficient purified diet containing tuna oil and stripped safflower seed oil (2,3 ). Fish oil is a rich source of PUFAs, which are highly susceptible to oxidation, and an increased intake of fish oil has been associated with increased vitamin E requirements. Currently the minimum dietary vitamin E requirement of cats has been set at 30 IU/kg dry matter with dietary levels expected to increase 3-4 times with a diet high in PUFAs (4 ). To prevent vitamin E deficiency in cats fed commercially sold diets, the Association of American Feed Control Officials (AAFCO) recommends that fish oil-containing diets for cats should be supplemented with 10 IU of vitamin E for every g of fish oil per kg diet (5 ). However, there is no direct evidence to substantiate the latter value or the increases recommended (4,5 ) in adult cats. The main objective of this study was to determine the vitamin E requirements of adult cats fed high dietary levels of PUFAs from fish oil. 
; Animals; Antioxidants; Blood/metabolism; Cats/physiology; Cell Division/drug effects; Concanavalin A/pharmacology; Dietary Fats; Unsaturated/administration & dosage; Erythrocytes/drug effects; Erythrocytes/physiology; Fatty Acids; Unsaturated/administration & dosage; Female; Ferric Compounds/metabolism; Fish Oils/administration & dosage; Hemolysis; Hydrogen Peroxide/pharmacology; Lymphocytes/cytology; Male; Nutritional Requirements; Oxidation-Reduction; Random Allocation; Vitamin E/administration & dosage; Nutrition; Fatty acids/