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6427445 
Journal Article 
Review 
Hypopituitarism due to hydrocephalus: case report and review of the literature 
Pinto, FC; da Cunha Neto, MB; Rocha, MG; Do Lago, DV; Bronstein, MD; Teixeira, MJ 
2011 
1 
Pediatric Neurosurgery
ISSN: 1016-2291
EISSN: 1423-0305 
47 
4 
303-306 
English 
22573017 
INTRODUCTION: Although rare, chronic hydrocephalus may cause amenorrhea and delayed puberty associated with obesity as the main endocrine manifestations. Since the first operation carried out in 1950 on a patient with amenorrhea and hydrocephalus, fewer than 30 patients with these features have been reported.

CASE REPORT: Our patient represents a teenage case of primary amenorrhea, partial adrenal insufficiency and adult growth hormone deficiency caused by hydrocephalus due to aqueductal stenosis. Our English-language literature search for similar well-documented cases yielded less than 30 cases. Our management consisted of endoscopic third ventriculostomy, which resulted in regular menstrual cycles and normalization of somato- and adrenocorticotropic axes.

DISCUSSION: This is a rare case of a 20-year-old woman with primary amenorrhea caused by hydrocephalus due to aqueductal stenosis. Neurosurgical treatment produced relief in hypothalamic hydrodynamics tension, allowing recovery of hormonal function and restoring normal menstrual cycles.