Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
6487
Reference Type
Journal Article
Title
Inhalation RfC methodology: Dosimetric adjustments and dose-response estimation of noncancer toxicity in the upper respiratory tract
Author(s)
Jarabek, AM
Year
1994
Is Peer Reviewed?
Yes
Journal
Inhalation Toxicology
ISSN:
0895-8378
EISSN:
1091-7691
Volume
6
Page Numbers
301-325
Web of Science Id
WOS:A1994QD17900022
URL
http://
://WOS:A1994QD17900022
Exit
Abstract
Environmental Protection Agency. Evaluation of noncancer toxicity involves the evaluation of an array of different adverse endpoints across various target tissues. The U.S. Environmental Protection Agency (EPA) inhalation reference concentration (RfC) methodology represents an approach for derivation of dose-response estimates for noncancer toxicity. The RfC methodology differs from other methodologies described at this symposium in that it incorporates dosimetric adjustments to account for species-specific relationships of exposure concentration to deposited/delivered dose in order to extrapolate across species. The physicochemical characteristics of the inhaled chemical are considered as key determinants to its interaction with respiratory tract components and ultimate deposition. This article discusses the RfC approach to noncancer toxicity with emphasis on the evaluation of toxicity in the upper respiratory tract (URT.). The derivation of default dosimetric adjustments for extrapolation of URT delivered dose across species is also presented. Areas of controversial interpretation or those requiring additional research are highlighted.
Tags
•
Formaldehyde [archived]
Nervous system effects
Found
Database search results
Snowball search
Screened
Title/abstract
Policy/ current practice-related
Retroactive RIS import
Pre2013
Merged LitSearch Additions 86 Reviews SCREEN
Ref List Citations 101112
2013
HCHON tox Ref Identification 022713
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
Other sources and cited references
Literature Identification
Nervous System Effects
Excluded
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity