Yamamoto, A; Morita, S; Hayashi, Y; Yamada, N; Kitamura, T
Benzamide derivatives of the following formula (I) ##STR1## [wherein R.sup.1 : ##STR2## B, D: hydrogen atom, etc. E: pyridyl group, etc. n: integer from 0 to 2 R.sup.2 : R.sup.3 R.sup.4 N-- etc. (R.sup.3,R.sup.4 : optionally substituted C.sub.6 -C.sub.14 aryl group, etc.) A; ##STR3## --CH.sub.2 --, --N.dbd.N--, --CH.dbd.N--, --N.dbd.CH--, --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --]. Optical antipodes thereof or pharmaceutically acceptable salts thereof, show excellent PAF antagonism and are effective for therapy and prophylaxis of diseases caused by PAF (bronchial asthma, nephritis, shocks, cardiac infarction, cerebral hemorrhage, ulcer, DIC, autoimmune diseases, thrombosis, etc.).