Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6- t -butyl- m -cresol) (CAS No. 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) | Health & Environmental Research Online (HERO)

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HERO ID

6557795

Reference Type

Technical Report

Title

Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6- t -butyl- m -cresol) (CAS No. 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Author(s)

National Toxicology Program (NTP) :: National Toxicology Program (NTP)

Year

1994

Report Number

NTP TR 435; NIH Publication No. 95-3166

Book Title

Technical Report Series

URL

http:////ntp.niehs.nih.gov/publications/reports/tr/400s/tr435/index.html?utm_source=direct&utm_medium=prod&utm_campaign=ntpgolinks&utm_term=tr435abs
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Abstract

4,4'-Thiobis(6- t -butyl- m -cresol) (TBBC) is used in the rubber and plastics industries as an antioxidant. TBBC is also used as a stabilizer in polyethylene and polyolefin packaging materials for foodstuffs. Toxicology and carcinogenesis studies were conducted by administering TBBC (99% pure) in feed to groups of male and female F344/N rats and B6C3F1 mice for 15 days, 13 weeks, and 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium and cultured Chinese hamster ovary cells.