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6579588 
Technical Report 
Toxicology and Carcinogenesis Studies of Roxarsone (Cas No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 
National Toxicology Program (NTP) :: National Toxicology Program (NTP) 
1989 
Research Triangle Park, NC 
TR-345 
Two-year toxicology and carcinogenesis studies were conducted by administering diets containing 0, 50, or 100 ppm roxarsone to groups of 50 rats of each sex. Diets containing 0, 100, or 200 ppm were fed to groups of 50 mice of each sex. Under the conditions of the studies, there was equivocal evidence of carcinogenic activity of roxarsone for male F344/N rats, as indicated by a marginally increased incidence of adenomas of the exocrine pancreas. There was no evidence of carcinogenic activity for female F344/N rats fed diets containing 50 or 100 ppm roxarsone for 2 years. There was no evidence of carcinogenic activity for male or female B6C3F1 mice fed diets containing 100 or 200 ppm roxarsone for 2 years.