US EPA

65923 

Journal Article 

Histopathological changes in liver and kidney of Mus booduga following oral benzenehexachloride (BHC) feeding 

Philip, GH; Sriraman, PK; Ramamurthi, R 

1989 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

42 

4 

499-502 

English 

2469506 

Adult mice (Mus-booduga) were given oral doses of 1,2,3,4,5,6-hexachlorocyclohexane (608731) (BHC) at a dose of 50 milligrams/kilogram/day for 1, 5, or 15 days. Congestion of portal vessels and central vein in the liver was observed on day one. The hepatic cells surrounding the portal areas were swollen and revealed parenchymatous degeneration with some vacuolar degeneration. By day five the liver demonstrated severe congestion of the central vein and portal vessels with severe fatty changes in periportal cells and mild fatty changes in centrolobular cells. By 15 days congestion of the central vein and portal vessels was noted with only granular degeneration being revealed in the periportal hepatocytes and the centrolobular cells. The kidney demonstrated congestion of blood vessels and glomerular tufts on day one. By the fifth day the tubules were swollen and revealed fatty changes, interstitial hemorrhages were seen in the medulla, cystic dilation of the tubules was evident, and hyaline casts were observed in the tubules. By 15 days the kidneys showed congestion of blood vessels and glomeruli, vacuolation in epithelial cells in the glomeruli, fatty changes in the tubules, cystic dilation of the tubules, and interstitial hemorrhages. The results indicate that BHC induced marked histological changes in both liver and kidney. The authors conclude that the histological results demonstrate that even at sublethal concentrations, chronic exposure to BHC can result in deleterious effects to these vital organs.