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6593107 
Journal Article 
Hoveyda-Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors 
Polyanskii, KB; Alekseeva, KA; Raspertov, PV; Kumandin, PA; Nikitina, EV; Gurbanov, AV; Zubkov, FI; , 
2019 
Yes 
Beilstein Journal of Organic Chemistry
ISSN: 1860-5397 
15 
769-779 
English 
30992725 
WOS:000463332200002 
A novel and efficient approach to the synthesis of 2-vinylbenzylamines is reported. This involves obtaining 2-vinylbenzylamine ligands from tetrahydroisoquinoline by alkylation and reduction followed by the Hofmann cleavage. The resultant 2-vinylbenzylamines allowed us to obtain new Hoveyda-Grubbs catalysts, which were thoroughly characterised by NMR, ESIMS, and X-ray crystallography. The utility of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10-2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM).