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HERO ID
6596304
Reference Type
Journal Article
Title
Combination of adsorption by porous CaCO3 microparticles and encapsulation by polyelectrolyte multilayer films for sustained drug delivery
Author(s)
Wang, C; He, C; Tong, Z; Liu, X; Ren, B; Zeng, F; ,
Year
2006
Is Peer Reviewed?
Yes
Journal
International Journal of Pharmaceutics
ISSN:
0378-5173
EISSN:
1873-3476
Publisher
ELSEVIER
Location
AMSTERDAM
Volume
308
Issue
1-2
Page Numbers
160-167
Language
English
PMID
16359836
DOI
10.1016/j.ijpharm.2005.11.004
Web of Science Id
WOS:000235102000021
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-30744434648&doi=10.1016%2fj.ijpharm.2005.11.004&partnerID=40&md5=9d0a76afecbdff8bd8b1f162fe1ddfd0
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Abstract
Combination of adsorption by porous CaCO(3) microparticles and encapsulation by polyelectrolyte multilayers via the layer-by-layer (LbL) self-assembly was proposed for sustained drug release. Firstly, porous calcium carbonate microparticles with an average diameter of 5 microm were prepared for loading a model drug, ibuprofen (IBU). Adsorption of IBU into the pores was characterized by ultraviolet (UV), infrared (IR), thermogravimetric analysis (TGA), Brunauer-Emmett-Teller (BET) experiment and X-ray diffraction (XRD). The adsorbed IBU amount Gamma was 45.1mg/g for one-time adsorption and increased with increasing adsorption times. Finally, multilayer films of protamine sulfate (PRO) and sodium poly(styrene sulfonate) (PSS) were formed on the IBU-loaded CaCO(3) microparticles by the layer-by-layer self-assembly. Amorphous IBU loaded in the pores of the CaCO(3) microparticles had a rapider release in the gastric fluid and a slower release in the intestinal fluid, compared with the bare IBU crystals. Polyelectrolyte multilayers assembled on the drug-loaded particles by the LbL reduced the release rate in both fluids. In this work, polymer/inorganic hybrid core-shell microcapsules were fabricated for controlled release of poorly water-soluble drugs. The porous inorganic particles are useful to load drugs in amorphous state and the polyelectrolyte multilayer films coated on the particle assuage the initial burst release.
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