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6597471 
Journal Article 
Vas deferens, a site of male contraception: an overview 
Lohiya, NK; Manivannan, B; Mishra, PK; Pathak, N; , 
2001 
Yes 
Asian Journal of Andrology
ISSN: 1008-682X
EISSN: 1745-7262 
WOLTERS KLUWER MEDKNOW PUBLICATIONS 
MUMBAI 
3 
2 
87-95 
English 
11404791 
WOS:000169801100002 
The vas deferens is a site which can be exploited for male contraception without undue side effects. The only effective technique available for male contraception is vasectomy, being practiced world wide, despite that it is a permanent surgical procedure and its successful reversal is not assured. Although no-scalpel vasectomy minimizes surgical procedures, the fate of its reversal is akin to that of vasectomy. Several occlusive and non-occlusive vasal procedures which claim to be reversible without surgical intervention, possess more disadvantages than advantages. Vas occlusion with plug, 'Shug' or medical grade silicone rubber, although claimed to produce reversible azoospermia without affecting spermatogenesis, requires skilled microsurgery for their implantation and later removal. RISUG, a non-sclerotic polymer styrene maleic anhydride (SMA), could be more advantageous than vasectomy and other vas occlusive procedures in that it could be a totally non-invasive procedure by "no-scalpel injection" and "non-invasive reversal". It is claimed to offer long-term contraception without adverse side effects and also to be possible as a male spacing method by repeated vas occlusion and non-invasive reversal. The drug is currently under multicentre Phase III clinical trial.