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6602294 
Journal Article 
Synthesis of N-(1-aziridinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acids 
Batori, S; Timari, G; Messmer, A; Podanyi, B; Vasvaridebreczy, L; Hermecz, I; , 
1997 
Yes 
Heterocycles
ISSN: 0385-5414 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
1097-1110 
WOS:A1997XJ90000007 
A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3-carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)(4) as oxidizing agent.