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6607060 
Journal Article 
Thietane 1,1-dioxides mono amine oxidase inhibitors, rat 
Wells, JN; Abbott, FS 
1966 
Yes 
Journal of Medicinal Chemistry
ISSN: 0022-2623
EISSN: 1520-4804 
9 
(4) 
489-492 
BCI:BCI19674800002697 
Cyclization of methanesulfonyl chloride with the appropriate enamine in the presence of triethylamine gave 3-alkylamino-2-phenylthietane 1,1-dioxides. In addition to cyclic products the acyclic derivatives, 2-dimethylamino- and 2-pyrrolidino-1-methanesulfonyl-l-phenylethylene were isolated. Some properties and chemistry are discussed. Reduction of the theitane 1,1-dioxides to the corresponding thietanes was unsuccessful. The thietane 1,1-dioxides were of interest as possible MAO [mono amine oxidase] inhibitors. None of the compounds tested showed significant in vitro MAO inhibitory activity. || ABSTRACT AUTHORS: Authors