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667279 
Journal Article 
Abstract 
A toxicological investigation of the acute, subchronic, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters 
Lawrence, WH; Malik, M; Turner, JE; Singh, AR; Autian, J 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
87-88 
English 
WOS:A1974T653800038 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Twelve esters of phthalic acid, including some of those most commonly used as plasticizers for biomedical devices, were subjected to one or more biological tests for acute, subchronic, and/or chronic toxicity. Certain aspects of subtle effects were investigated as well as overt toxic manifestations. The acute, ip LD50 of these compounds in mice ranged from 3.22 to more than 100 g/kg. A cornparision of the acute to chronic LD50 values reveals most of these phthalates are 2-4 times more toxic chronically. However, di-n-octyl phthalate (DOP) was almost 22 times more toxic chronically, and the chronic toxicity of di-2-ethylhexyl phthalate (DEHP) was about 28 times greater. Pre-treatment of mice with these phthalate esters generally resulted in an increase in pentobarbital sleeping time. A 12-week subchronic study of di-2-ethylhexyl phthalate in rats revealed very few abnormalities which could be attributed to the phthalate ester. Some of the new data are discussed in relation to previously published results of similar studies. 
pentobarbital; phthalic acid bis(2 ethylhexyl) ester; phthalic acid derivative; drug toxicity; intraperitoneal drug administration; LD 50; mouse; sleep time; theoretical study 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, DC 
March 10-14, 1974