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66968 
Journal Article 
The carcinogenic effects of 4,4'-methylene-bis-(2-chloroaniline) in mice and rats 
Russfield, AB; Homburger, F; Boger, E; Van Dongen, CG; Weisburger, EK; Weisburger, JH 
1975 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
31 
1 
47-54 
English 
1129788 
WOS:A1975V472400006 
As part of a series of bioassays of industrial and environmental chemicals for chronic toxicity or carcinogenicity, 4,4'-methylene-bis-(2-chloroaniline) was tested in male and female random bred albino mice and male Charles River CD rats. Preliminary studies established that the maximally tolerated dose of the chemical in the diet was 1000 mg/kg in rats and 2000 mg/kg in mice. The compound, at these dose levels and 1/2 the level, was fed to male and female mice and male rats for 18 mo., followed by a control diet for another 6 mo. In female mice but not in males, a statistically significant incidence of hepatoma at both dose levels was observed. A higher incidence of tumors was also observed in treated animals than in controls as follows: hepatomas and lung adenomatosis in rats, hemangiosarcomas and hemangiomas in mice. 4,4'-Methylene-bis-(2-chloroaniline) is carcinogenic in female mice. 
Aniline Compounds; Carcinogens; Index Medicus; Animals; Body Weight -- drug effects; Neoplasms, Experimental -- pathology; Mice, Inbred ICR; Aniline Compounds -- toxicity; Aniline Compounds -- pharmacology; Carcinogens -- pharmacology