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Citation
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HERO ID
6713280
Reference Type
Journal Article
Subtype
Review
Title
The Molecular Pathophysiology of Concussive Brain Injury - an Update
Author(s)
Barkhoudarian, G; Hovda, DA; Giza, CC
Year
2016
Is Peer Reviewed?
0
Journal
Physical Medicine and Rehabilitation Clinics of North America
ISSN:
1047-9651
Volume
27
Issue
2
Page Numbers
373-393
Language
English
PMID
27154851
DOI
10.1016/j.pmr.2016.01.003
Web of Science Id
WOS:000377055700003
Abstract
Concussion, or mild traumatic brain injury (TBI), affects millions of patients worldwide. Understanding the pathophysiology of TBI can help manage its repercussions. The brain is significantly altered immediately following mild TBI because of metabolic, hemodynamic, structural, and electrophysiologic changes. This process affects cognition and behavior and can leave the brain vulnerable for worse injury in the setting of repeat insult. This article is an update of our previously published review, reporting relevant and current studies from the bench to the bedside of mild TBI. Understanding the pathobiology can help prevent and treat mild TBI.
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