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6713280 
Journal Article 
Review 
The Molecular Pathophysiology of Concussive Brain Injury - an Update 
Barkhoudarian, G; Hovda, DA; Giza, CC 
2016 
0 
Physical Medicine and Rehabilitation Clinics of North America
ISSN: 1047-9651 
27 
2 
373-393 
English 
27154851 
WOS:000377055700003 
Concussion, or mild traumatic brain injury (TBI), affects millions of patients worldwide. Understanding the pathophysiology of TBI can help manage its repercussions. The brain is significantly altered immediately following mild TBI because of metabolic, hemodynamic, structural, and electrophysiologic changes. This process affects cognition and behavior and can leave the brain vulnerable for worse injury in the setting of repeat insult. This article is an update of our previously published review, reporting relevant and current studies from the bench to the bedside of mild TBI. Understanding the pathobiology can help prevent and treat mild TBI.