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Citation
Tags
HERO ID
6715799
Reference Type
Journal Article
Subtype
Review
Title
Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
Author(s)
Bopp, SK; Kienzler, A; Richarz, AN; van der Linden, SC; Paini, A; Parissis, N; Worth, AP
Year
2019
Is Peer Reviewed?
Yes
Journal
Critical Reviews in Toxicology
ISSN:
1040-8444
EISSN:
1547-6898
Volume
49
Issue
2
Page Numbers
174-189
Language
English
PMID
30931677
DOI
10.1080/10408444.2019.1579169
Web of Science Id
WOS:000464618900001
Abstract
This paper summarizes current challenges, the potential use of novel scientific methodologies, and ways forward in the risk assessment and risk management of mixtures. Generally, methodologies to address mixtures have been agreed; however, there are still several data and methodological gaps to be addressed. New approach methodologies can support the filling of knowledge gaps on the toxicity and mode(s) of action of individual chemicals. (Bio)Monitoring, modeling, and better data sharing will support the derivation of more realistic co-exposure scenarios. As knowledge and data gaps often hamper an in-depth assessment of specific chemical mixtures, the option of taking account of possible mixture effects in single substance risk assessments is briefly discussed. To allow risk managers to take informed decisions, transparent documentation of assumptions and related uncertainties is recommended indicating the potential impact on the assessment. Considering the large number of possible combinations of chemicals in mixtures, prioritization is needed, so that actions first address mixtures of highest concern and chemicals that drive the mixture risk. As chemicals with different applications and regulated separately might lead to similar toxicological effects, it is important to consider chemical mixtures across legislative sectors.
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