Health & Environmental Research Online (HERO)


Print Feedback Export to File
6716873 
Journal Article 
The Role of NMDA Receptors in Alzheimer's Disease 
Liu, J; Chang, L; Song, Y; Li, Hui; Wu, Yan; , 
2019 
Yes 
Frontiers in Neuroscience
ISSN: 1662-4548 
FRONTIERS MEDIA SA 
LAUSANNE 
30800052 
WOS:000458256600001 
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.