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671728 
Journal Article 
Effect of streptozotocin administration to pregnant mice on serum glucose, glycosylated hemoglobin and weight of organs of the mother mice and their pups 
Fujii, E; Nomoto, T 
1988 
Yes 
Japanese Journal of Pharmacology
ISSN: 0021-5198
EISSN: 1347-3506 
48 
3 
391-394 
English 
2975722 
Administration of streptozotocin (STZ, 200 mg/kg, i.p.) to pregnant mice during either the early or middle stages of pregnancy produced diabetic conditions in the mother mice. It reduced the litter size, but did not induce diabetes in the pups. The weights of the liver and kidney per unit body weight of the infants of STZ-treated mother mice were slightly larger, though not significantly, than that of infants from control mothers; however, no increase was observed in the blood glucose or glycosylated hemoglobin (HbA1) values. 
Animals; Blood Glucose/*metabolism; Diabetes Mellitus, Experimental/blood/*complications/pathology; Female; Hemoglobin A, Glycosylated/*metabolism; Kidney/drug effects/pathology; Liver/drug effects/pathology; Maternal-Fetal Exchange; Mice; Organ Size/drug effects; Pregnancy; Pregnancy in Diabetics/*blood/pathology; Streptozocin/toxicity; 0 (Blood Glucose); 0 (Hemoglobin A, Glycosylated); 18883-66-4 (Streptozocin)