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6734529 
Journal Article 
Review 
Biological role of Toll-like receptor-4 in the brain 
Trotta, T; Porro, C; Calvello, R; Panaro, MA 
2014 
Yes 
Journal of Neuroimmunology
ISSN: 0165-5728
EISSN: 1872-8421 
268 
1-2 
1-12 
English 
24529856 
WOS:000333730200001 
The Toll-like receptors (TLRs) are a family of microbe-sensing receptors that play a central role in the regulation of the host immune system. TLR4 has been described in the brain and seems to regulate some physiological processes, such as neurogenesis. TLR4 has also been reported to play a role during neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease. This review is focused on reports concerning recent insights into the role and activation mechanisms of TLR4 in the brain, in pathological and physiological conditions, as well as the therapeutic benefit that could derive from TLR4 modulation.