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67355 
Journal Article 
The chronic toxicity of hexamethylphosphoramide in rats 
Kimbrough, R; Gaines, TB 
1973 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
10 
4 
225-226 
English 
4755260 
WOS:A1973R023900005 
Several years ago we studied the acute and subacute toxicity of hexamethylphosphoramlde (HMPA) (Kimbrough and Gaines 1966). PAMPA had been suggested as a chemosterilant for houseflies (Chang et al. 1964). In our studies atrophy of the testes was observed in adult male rats fed 750 ppm (80-40 mg/kg/day) in the diet for 61-103 days. A high incidence of pneumonia was also found in the poisoned animals. This finding was further investigated (Kimbrough, R.D. and Sedlak, V.A., 1968). Corresponding observations were made by Jackson et al. (1966, 1969). Shott et al. (1971) reported e reproduction study where 2 and i0 mg-~kg-l~4PA were given to male and female rats daily for 169 days. Reproduction was not affected but a high incidence of murine pneumonia was observed. Following our preliminary study (Kimbrough and Gaines 1966) we investigated the toxicity of PAMPA in a long term study in rats with lower dietary levels. It is the purpose of this communication to report very briefly the main findings of that study.