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6748432 
Journal Article 
Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers 
Eshkoor, SA; Ismail, P; Rahman, SA; Adon, MY; Devan, RV 
2013 
1 
Toxicology Mechanisms and Methods
ISSN: 1537-6516
EISSN: 1537-6524 
INFORMA HEALTHCARE 
LONDON 
23 
4 
217-222 
English 
23193996 
WOS:000318363100001 
Aging is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate aging. Cytochrome P450 2E1 (CYP2E1) gene contributes in activation and detoxification of the environmental hazards. This polymorphism plays an important role in susceptibility of inter-individuals to DNA damage at the occupational exposure. The current study evaluated the possible influence of this gene polymorphism in aging by genomic damages through the biomarkers alterations of micronuclei (MN), comet tail length and telomere length shortening at the exposure. In this study, buccal cells were collected from the oral cavity of exposed workers and non-exposed controls. The CYP2E1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The wild genotype significantly affected MN frequency (p = 0.007) and relative telomere length (p = 0.047) in the older group of workers. It was concluded that the interaction of gene polymorphism and exposure enhances DNA damage and accelerates aging consequently.