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6751286 
Journal Article 
Review 
An update on the epigenetics of psychotic diseases and autism 
Abdolmaleky, HM; Zhou, JR; Thiagalingam, S 
2015 
Yes 
Epigenomics
ISSN: 1750-1911 
7 
3 
427-449 
English 
26077430 
WOS:000356241700009 
The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide studies of postmortem brain and blood cells indicating that aberrant DNA methylation, histone modifications and dysregulation of micro-RNAs are linked to the pathogenesis of mental diseases. There is also strong evidence supporting that all classes of psychiatric drugs modulate diverse features of the epigenome. While comprehensive environmental and genetic/epigenetic studies are uncovering the origins, and the key genes/pathways affected in psychotic diseases, characterizing the epigenetic effects of psychiatric drugs may help to design novel therapies in psychiatry.