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6768910 
Journal Article 
The age-related change of glutathione antioxidant system in mice liver 
Jiang, P; Sheng, Y; Ji, L 
2013 
1 
Toxicology Mechanisms and Methods
ISSN: 1537-6516
EISSN: 1537-6524 
23 
6 
396-401 
English 
23343351 
WOS:000321065600003 
Cellular glutathione (GSH) antioxidant system is an important defensive system of the body, which is crucial in the protection against oxidative stress-induced liver injury. The present study was designed to observe the difference of this system in the liver of mice with 1-month- and 12-month-old. Liver reduced GSH level was showed no difference between these two groups of mice. Next, the results showed that liver glutamate-cysteine ligase (GCL) activity was higher in mice of 1-month- than 12-month-old, while glutathione-S-transferase (GST) activity was higher in mice of 12-month- than 1-month-old. Further results showed that the higher activity of liver GCL in 1-month-old mice was due to the higher expression of catalytic subunit of GCL (GCLc) mRNA, while the higher activity of liver GST in 12-month-old mice might be due to the higher expression of GSTA1, GSTA2, GSTP1 and GSTP2 mRNA. Taken together, our results revealed the age-related change of liver GSH antioxidant system in mice, which may be helpful for elucidating some age-related liver injury or diseases.