Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
6775139
Reference Type
Journal Article
Subtype
Review
Title
Long-term depression in the CNS
Author(s)
Collingridge, GL; Peineau, S; Howland, JG; Wang, YT
Year
2010
Is Peer Reviewed?
1
Journal
Nature Reviews. Neuroscience
ISSN:
1471-003X
EISSN:
1471-0048
Volume
11
Issue
7
Page Numbers
459-473
Language
English
PMID
20559335
DOI
10.1038/nrn2867
Web of Science Id
WOS:000278925600009
Abstract
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity