Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6777800

Reference Type

Journal Article

Title

Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats

Author(s)

Kang, MH; Lee, MS; Choi, MK; Min, KS; Shibamoto, T

Year

2012

Is Peer Reviewed?

Yes

Journal

Journal of Agricultural and Food Chemistry
ISSN: 0021-8561
EISSN: 1520-5118

Volume

Issue

Page Numbers

2517-2524

Language

English

PMID

22360666

DOI

10.1021/jf205086b

Web of Science Id

WOS:000301407000015

Abstract

Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats. The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.